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Tumeric (Curcumin)

Our Overview

Turmeric is a popular spice that has been used for medicinal purposes in humans for centuries. It is also sometimes used in veterinary medicine, particularly in dogs. Turmeric contains an active ingredient called curcumin, which has anti-inflammatory, antioxidant, and antifungal properties.

In dogs, turmeric has been used as a supplement to help manage a variety of health conditions, including arthritis, allergies, and gastrointestinal issues. However, before giving turmeric to your dog, it is important to speak with a veterinarian to ensure it is safe and appropriate for your pet’s specific health needs.

In terms of medical interactions, turmeric may interact with certain medications, including blood thinners, anti-inflammatory drugs, and chemotherapy drugs. It is important to talk to your veterinarian before giving turmeric to your dog if your dog is taking any medications.

Additionally, turmeric may cause gastrointestinal upset in some dogs, particularly if given in large doses. It is also possible for turmeric to cause allergic reactions in dogs who are sensitive to it. If you notice any adverse reactions in your dog after giving turmeric, you should discontinue use and contact your veterinarian.

Curcumin, the active ingredient in turmeric, has been extensively studied for its potential health benefits in humans and, to a lesser extent, in animals. While there is some evidence to support the use of curcumin as a supplement in dogs, more research is needed to fully understand its effectiveness and safety.

Studies have suggested that curcumin may have anti-inflammatory, antioxidant, and antimicrobial properties, which could potentially benefit dogs with certain health conditions. For example, a study published in the Journal of the American Veterinary Medical Association in 2012 found that curcumin supplementation improved clinical signs of osteoarthritis in dogs.

However, it is important to note that many of the studies on curcumin in dogs are small and/or have limitations, such as a lack of placebo control or a short study duration. More research is needed to determine the optimal dose, frequency, and duration of curcumin supplementation in dogs, as well as its potential interactions and side effects.

Overall, while there is some scientific evidence to support the use of curcumin as a supplement in dogs, more research is needed before it can be fully validated as an effective and safe treatment option. It is important to speak with a veterinarian before giving any supplement to your dog and to monitor your dog for any adverse reactions or changes in health.

Background

Turmeric is the dried rhizome (root) of Curcuma longa (wild turmeric), Curcuma wenyujin (China), and Curcuma domestica (Thailand). It is a rhizomatous herbaceous perennial plant that belongs to the Zingiberaceae family. Turmeric has been identified as having over 133 different species. Its native range includes the Indian subcontinent and Southeast Asia. Turmeric contains over 235 active ingredients that are naturally packed into its root and are optimally proportioned. These complex phytochemicals (>235), which include essential oils, curcuminoids (>89), and turmerosaccharides, as well as curcuminoid-free ingredients, fibre, and their metabolites and products of microbial degradation of standardised turmeric, may act as a modulator of dysregulated chronic immune inflammation and pain in disease states in humans, pets, and horses in an additive or synergistic fashion.

One of the fundamental principles of Ayurvedic medicine is that efficacy cannot be related to plasma levels of a major active ingredient in a spice or herb, and that the whole herb is often more effective than its individual ingredients. Contrary to this basic principle, R&D teams have dramatically improved the bioavailability of curcumin, turmeric’s main active ingredient, over the last few decades. Researchers increased the dose of curcumin in most clinical trials conducted so far without improving its efficacy in cancer and Alzheimer’s disease.

Standardized turmeric containing curcumin could achieve steady-state therapeutic levels in the brains of patients or pets suffering from Alzheimer’s disease or other persistent dysregulated chronic immune inflammatory conditions within 3-10 days. This idea could be tested on ageing dogs, cats, and horses with OA and mild dementia. This concept is based on preclinical studies that show aspirin and curcumin have similar effects in vitro and in vivo. It was unthinkable twenty to thirty years ago that 81 mg aspirin could reduce the risk of stroke and heart attack.

A low dose of standardised turmeric combined with coconut oil or fish oil may help pets with age-related, persistent, dysregulated chronic immune inflammation in the brain, eyes, skin, muscles, gut, and other internal organs. It has the potential to slow the progression of cognitive decline disorder (CCD) in dogs and cats. A low dose of standardised turmeric may be used as an adjunct therapy in the management of many disease states in ageing pets, including dogs, cats, and horses. Turmeric ingredients may restore homeostasis in the brain, joints, gut, and other tissues only in disease states, acting through a variety of interconnected mechanisms.

Side Effects

Tumeric is generally thought to be very safe. That said, there are potentially a few minor side effects that might make your dog uncomfortable. Stomach upsets or constipation are possible side effects, especially if you take too much at once. If your dog exhibits these symptoms, you could begin with a lower dose and gradually increase to the recommended amount. If your dog is prone to kidney stones, turmeric tablets may exacerbate the problem by increasing urinary oxalate levels. This increases the likelihood of kidney stone formation. Turmeric is known as a “warming” spice, so if your dog is always hot and searches for cool floors to lie on, then don’t give him turmeric.

Interactions

Curcumin may interact with certain medications, including blood thinners, anti-inflammatory drugs, and chemotherapy drugs. It is important to talk to your veterinarian before giving curcumin to your dog if your dog is taking any medications. Turmeric paste, tablets or supplements might not be appropriate if your dog is being treated for diabetes, and turmeric can help lower blood sugar levels. If your pet is about to have surgery it is best to stop giving turmeric to your dog at least a month in advance.

It is also important to use high-quality turmeric from a reputable source, as some turmeric products may be contaminated or may contain other harmful additives.

Indications

  • Cancer
  • Kidney Stones
  • Psoriasis
  • Allergies
  • Eye Diseases
  • Diabetes
  • Metabolic Syndrome
  • Cognitive Decline
  • Sports Medicine
  • Pain Management
  • Osteoarthritis
  • Digestive System

Dose Recommendations

A typical recommended dose is between 3 and 4mg per kg. For best results, give your dog a little every day to gradually build up the amount of curcumin in their system – there’s no need to rush. As Curcumin does not stay in the body for extended periods of time it is thought that little and often is the best approach with dosing every 6 hours.

Reported doses measured by the “Teaspoon” are:

  • Small dogs (under 20 pounds): 1/8 to 1/4 teaspoon of turmeric per day
  • Medium dogs (20-50 pounds): 1/4 to 1/2 teaspoon of turmeric per day
  • Large dogs (over 50 pounds): 1/2 to 1 teaspoon of turmeric per day

Contraindications

Turmeric can interact with some medications, including diabetic and anti-inflammatory medications. It may also interfere with some chemotherapy treatments. Therefore check with your vet before giving it to your dog.

Curcumin may cause gastrointestinal upset in some dogs, particularly if given in large doses or if the dog has a sensitive stomach. While rare, some dogs may have an allergic reaction to curcumin. Signs of an allergic reaction may include swelling, hives, itching, difficulty breathing, or vomiting. If you notice any of these signs, stop giving curcumin and contact your veterinarian.

Products containing Tumeric (Curcumin)

Your experience with Tumeric (Curcumin)

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Further Reading

  1. Agarwal KA, Tripathi CD, Agarwal BB et al (2011) Efficacy ofturmeric (curcumin) in pain and postoperative fatigue after laparoscopic cholecystectomy: a double-blind, randomized placebo-controlled study. Surg Endosc 25(12):3805-3810
  2. Aggarwal BB, Yuan W, Li S et al (2013) Curcumin-free turmeric exhibits anti-inflammatory and anticancer activities: identification of novel components of turmeric. Mol Nutr Food Res 57 (9):1529-1542
  3. Akuri MC, Barbalho SM, Val RM et al (2017) Reflections about osteoarthritis and Curcuma longa. Pharmacogn Rev 1(21):8-12 Alipour A, Elte JW, van Zaanen HC et al (2007) Postprandial inflam­mation and endothelial dysfunction. Biochem Soc Trans 35 (Pt 3):466-469
  4. Arun N, Nalini N (2002) Efficacy ofturmeric on blood sugar and polyol pathway in diabetic albino rats. Plant Foods Hum Nutr 57(1):41-52 Ashraf K, Mujeeb M, Ahmad A et al (2015) Determination of curcuminoids in Curcuma longa Linn. by UPLC/Q-TOF-MS: an application in turmeric cultivation. J Chromatogr Sci 53 (8):1346-1352
  5. Bas M, Tugcu V, Kemahli E et al (2009) Curcumin prevents shock­ wave lithotripsy-induced renal injury through inhibition of nuclear factor kappa-B and inducible nitric oxide synthase activity in rats. Urol Res 37(3):159-164
  6. Bastaki SMA, Ahmed MMA, Zaabi AA et al (2016) Effect ofturmeric on colon histology, body weight, ulcer, IL-23, MPO and glutathione in acetic-acid induced inflammatory bowel disease in rats. BMC Complement Altera Med 16:72
  7. Begum AN, Jones MR, Lim GP et al (2008) Curcumin structure­ function, bioavailability, and efficacy in models of neuroinflammation and Alzheimer’s disease. J Pharmacol Exp Tuer 326(1):196-208
  8. Bethapudi B, Murugan S, Illuri R et al (2017) Bioactive turmerosac­ charides from Curcuma longa extract (NR-INF-02): potential ameliorating effect on osteoarthritis pain. Pharmacogn Mag 13 (Suppl 3):S623-S627
  9. Betts JW, Sharili AS, La Ragione RM (2016) In vitro antibacterial activity of curcumin-polymyxin B combinations against multidrug-resistant bacteria associated with traumatic wound infections. J Nat Prod 79(6):1702-1706
  10. Bland SD, Venable EB, McPherson JL et al (2017) Effects ofliposomal­ curcumin on five opportunistic bacterial strains found in the equine hindgut – preliminary study. J Anim Sci Technol 59:15
  11. Bolger GT, Licollari A, Tan A et al (2017) Distribution and metabolism of Lipocurc™ (liposomal curcumin) in dog and human blood cells:
    Standardized Turmeric and Curcumin 21 species selectivity and pharmacokinetic relevance. Anticancer Res 37(7):3483-3492
  12. Bolger GT, Licollari A, Tan A et al (2018) Distribution of curcumin and THC in peripheral blood mononuclear cells isolated from healthy individuals and patients with chronic Iymphocytic leukemia. Anti­ cancer Res 38(1):121-130
  13. Brumatti LV, Marcuzzi A, Tricarico PM et al (2014) Curcumin and inflammatory Bowel disease: potential and limits of innovative treatments. Molecules 19:21127-21153
  14. Cavaleri F (2018) Presenting a new standard drug model for turmeric and its prized extract, curcumin. Int J Inflam 1(15):5023429
  15. Chand N (2018) Composition of containing standardized turmeric for reducing inflammation. Provisional Patent Application # 626136994, Jan 4, 2018
  16. Cheppudira B, Fowler M, McGhee Let al (2013) Curcumin: a novel therapeutic for bum pain and wound healing. Expert Opin Investig Drugs 22:295-1230
  17. Colitti M, Gaspardo B, Della Pria A et al (2012) Transcriptome modifi­ cation of white blood cells after dietary administration of curcumin and non-steroidal anti-inflammatory drug in osteoarthritic affected dogs. Vet Immunol Immunopathol 147:136-146
  18. Das P, Gupta G, Velu Vet al (2017) Formation of struvite urinary stones and approaches towards the inhibition – a review. Biomed Pharmacother 96:361-370
  19. Del Grossi Moura M, Lopes LC, Biavatti MW et al (2017) Oral herbal medicines marketed in Brazil for the treatment of osteoarthritis: a systematic review and meta- analysis. Phytother Res 31:1676-1685 Dende C, Meena J, Nagarajan Pet al (2017) Nanocurcumin is superior to native curcumin in preventing degenerative changes in Experi­mental Cerebral Malaria. Sci Rep 7(1):10062
  20. Di Pierro F, Bressan A, Ranaldi D et al (2015) Potential role ofbioavail­ able curcumin in weight loss and omental adipose tissue decrease: preliminary data of a randomized, controlled trial in overweight people with metabolic syndrome. Preliminary study. Eur Rev Med Pharmacol Sci 19:4195-4202
  21. Dou Y, Luo J, Wu X (2018) Curcumin attenuates collagen-induced inflammatory response through the “gut-brain axis”. J Neuroinflammation 15(1):6
  22. Farinacci M, Colitti M, Stefanon B (2009) Modulation of ovine neutro­ phil function and apoptosis by standardized extracts of Echinacea angustifolia, Butea frondosa and Curcuma longa. Vet Immunol Immunopathol 128(4):366-373
  23. Fujiwara H (2000) Curcumin inhibits glucose production in isolated mice hepatocytes. Diabetes Res Clin Pract 80:185-190
  24. Gaffey A, Campbell J, Porritt Ket al (2015) The effects of curcumin on musculoskeletal pain: a systematic review protocol. JBI Database System Rev Implement Rep 13:59-73
  25. Gera M, Sharma N, Ghosh M et al (2017) Nanoformulations of curcumin: an emerging paradigm for improved remedial application. Oncotarget 8:66680-66698
  26. Ghodasara J, Pawar A, Deshmukh C et al (2010) Inhibitory effect of rutin and curcumin on experimentally-induced calcium oxalate uro­ lithiasis in rats. Pharmacogn Res 2:388-392
  27. Ghosh SS, He H, Wang Jet al (2018) Curcumin-mediated regulation of intestinal barrier function: the mechanism underlying its beneficial effects. Tissue Barriers 6(1):el425085
  28. Gopi S, Jacob J, Varma K et al (2017) Comparative oral absorption of curcumin in a natural turmeric matrix with two other curcumin formulations: an open-label parallel-arm study. Phytother Res 31:1883-1891
  29. Gopinath H, Karthikeyan K (2018) Turmeric: a condiment, cosmetic and cure. Indian J Dermatol Venereol Leprol 84:16-21 Gupta SC, Kismali G, Aggarwal BB (2013) Curcumin, a component of turmeric: from farm to pharmacy. Biofactors 39:2-13
  30. Gutierres VO, Campos ML, Arcaro CA et al (2015) Curcumin pharma­ cokinetic and pharmacodynamic evidences in streptozotocin­ diabetic rats support the antidiabetic activity to be via metabolite (s). Evid Based Complement Altemat Med 2015:678218
  31. Han S, Xu J, Guo X et al (2018) Curcumin ameliorates severe influenza pneumonia via attenuating lung injury and regulating macrophage cytokines production. Clin Exp Pharmacol Physiol 45(1):84-93
  32. Hanai H, Sugimoto K (2009) Curcumin has bright prospects for the treatment of inflammatory Bowel disease. Curr Pharm Des 15 (18):2087-2094
  33. Hanai H, Iida T, Takeuchi Ket al (2006) Curcumin maintenance therapy for ulcerative colitis: randomized, multicenter, double-blind, pla­cebo controlled trial. Clin Gastroenterol Hepatol 4(12):1502-1506
  34. Haroyan A, Mukuchyan V, Mkrtchya Net al (2018) Efficacy and safety of curcumin and its combination with boswellic acid in osteoarthri­tis: a comparative, randomized, double- blind, placebo-controlled study. BMC Complement Altem Med 18(1):7
  35. Heaton LE, Davis JK, Rawson ES et al (2017) Selected in-season nutritional strategies to enhance recovery for team sport athletes: a practical overview. Sports Med 47(11):2201-2218
  36. Hu X, Huang F, Szymusiak Met al (2016) PLGA-Curcumin attenuates opioid-induced hyperalgesia and inhibits spinal CaMKIIa. PLos One ll:e0l46393
  37. Innes JF, Fuller CJ, Grover ER et al (2003) Randomized, double- blind, placebo controlled parallel group study of P54FP for the treatment of dogs with osteoarthritis. Vet Rec 152:457-460
  38. Javeri I, Chand N (2016) Curcumin. In: Gupta RC (ed) Nutraceuticals: efficacy, safety and toxicity. Academic Press, Amsterdam, pp 435-445
  39. Jeengar MK, Shrivastava S, Mouli Veeravalli SC (2016) Amelioration of FCA induced arthritis on topical application of curcumin in combination with emu oil. Nutrition 32:955-964
  40. Jia S, Du Z, Song C et al (2017) Identification and characterization of curcuminoids in turmeric using ultra-high-performance liquid chromatography quadrupole time of flight tandem mass spectrome­ try. J Chromatogr A 1521:110-122
  41. Jin TR (2018) Curcumin and dietary polyphenol research: beyond drug discovery. Acta Pharmacol Sin 39(5):779-786
  42. Krausz AE, Adler BL, Cabral V (2015) Curcumin-encapsulated nanoparticles as innovative antimicrobial and wound healing agent. Nanomedicine 11:195-206
  43. Kumar SSD, Houreld NN, Abrahamse H (2018) Therapeutic potential and recent advances of curcumin in the treatment of aging-associated diseases. Molecules 23(4):835-849
  44. Kurup V, Barrios CS, Barrios R et al (2007) Immune response modula­ tion by curcumin in a latex allergy model. Clin Mol Allergy 5(1):1
  45. Lang A, Salomon N, Wu JC et al (2015) Curcumin in combination with mesalamine induces remission in patients with mild-to-moderate ulcerative colitis in a randomized controlled trial. Clin Gastroenterol Hepatol 13(8):1444-1449
  46. Lim GP, Chu T, Yang Fetal (2001) The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse. J Neurosci 21:8370-8377
  47. Lin J-A, Chen J-H, Lee Y-W et al (201 I) Biphasic effect of curcumin on morphine tolerance: a preliminary evidence from cytokine/chemo­ kine protein array analysis. Evid Based Complement Altemat Med 2011:452153.
  48. Liu Q, Yin W, Han Let al (2018a) Diarylheptanoid from rhizomes of Curcuma kwangsiensis (DCK) inhibited imiquimod-induced den­ dritic cells activation and Th I/Th17 differentiation. Int Immunopharmacol 56:339-348
  49. Liu X, Machado GC, Eyles JP et al (2018b) Dietary supplements for treating osteoarthritis: a systematic review and meta-analysis. Br J Sports Med 52:167-175 22
  50. N.Chand. Lone PA, Ahmed SW, Prasad V et al (2018) Role of turmeric in management of alveolar osteitis (dry socket): a randomized clinical study. J Oral Biol Craniofac Res 8:44-47
  51. Mantzorou M, Pavlidou E, Vasios Get al (2018) Effects of curcumin consumption on human chronic diseases: a narrative review of the most recent clinical data. Phytother Res 32:957-975.
  52. Maradana MR, Thomas R, O’Sullivan BJ (2013) Targeted delivery of curcumin for treating type 2 diabetes. Mol Nutr Food Res 57:550-1556
  53. Matabudul D, Pucaj K, Bolger G et al (2012) Tissue distribution of (Lipocurc™) liposomal curcumin and tetrahydrocurcumin following two- and eight-hour infusions in Beagle Dogs. Anticancer Res 32:4359-4364
  54. Mazzanti G, Di Giacomo S (2016) Curcumin and resveratrol in the management of cognitive disorders: what is the clinical evidence? Molecules 21:1243-1270
  55. McCann MJ, Johnston S, Reilly Ket al (2014) The effect of turmeric (Curcuma longa) extract on the functionality of the solute carrier protein 22 A4 (SLC22A4) and interleukin-IO (IL-10) variants associated with inflammatory bowel disease. Nutrients 6:4178-4190
  56. McCubrey JA, Lertpiriyapong K, Steelman LS et al (2017) Regulation of GSK-3 activity by curcumin, berberine and resveratrol: potential
    effects on multiple diseases. Adv Biol Reg 65:77-88
  57. McFarlin BK, Venable AS, Henning AL et al (2016) Reduced inflam­ matory and muscle damage biomarkers following oral supplementa­tion with bioavailable curcumin. BBA Clin 5:72-78
  58. Mollazadeh H, Cicero AFG, Blesso CN et al (2017) Immune modulation by curcumin: the role of interleukin-IO. Crit Rev Food Sci Nutr:1-13.
  59. Motaghinejad M, Bangash MY, Hosseini P (2015) Attenuation of mor­ phine withdrawal syndrome by various dosages of curcumin in comparison with clonidine in mouse: possible mechanism. IJMS 40:125-132
  60. Murugan S, Bethapudi B, Purusothaman D et al (2017) Anti-arthritic effect of polar extract of Curcuma longa on monosodium iodoacetate induced osteoarthritis in rats. Antiinflamm Antiallergy Agents Med Chem 16(3):193-202
  61. Nalli M, Ortar G, Schiano Moriello A et al (2017) Effects of curcumin and curcumin analogues on TRP channels. Fitoterapia 122:126-131
  62. Neto FC, Marton LT, de Marqui SV et al (2018) Curcuminoids from Curcuma Longa: new adjuvants for the treatment of Crohn’s disease and ulcerative colitis? Crit Rev Food Sci Nutr 22:1-36
  63. Nirumand MC, Hajialyani M, Rahimi R et al (2018) Dietary plants for the prevention and management of kidney stones: preclinical and clinical evidence and molecular mechanisms. Int J Mol Sci 19:765
  64. Ohno M, Nishida A, Sugitani S et al (2017) Nanoparticle curcumin ameliorates experimental colitis via modulation of gut microbiota and induction of regulatory T cells. PLoS One 12(10):e0185999
  65. Peddada KV, Brown A, Verma Vet al (2018) Therapeutic potential of curcumin in major retinal pathologies. Int Ophthalmol.
  66. Ponnusamy S, Zinjarde S, Bhargava S et al (2012) Discovering Bisdemethoxycurcumin from Curcuma longa rhizome as a potent small molecule
  67.  inhibitor of human pancreatic a-amylase, a target for type-2 diabetes. Food Chem 135:2638-2642
  68. Prasad S, Aggarwal BB (2011) Chapter 13: Turmeric, the golden spice. From traditional medicine to modem medicine. In: Benzie IFF, Wachtel-Galor S (eds) Herbal medicine: biomolecular and clinical aspects.
  69. CRC Press, Boca Raton, FLRamirez BA, Soler A, Carrion-Gutierrez MA et al (2000) An hydroalcoholic extract of Curcuma longa lowers the abnormally high values of human-plasma fibrinogen. Mech Ageing Dev 114 (3):207-210
  70. Ramkumar M, Rajasankar S, Gobi VV et al (2018) Demethoxy­ curcumin, a natural derivative of curcumin abrogates rotenone­ induced dopamine depletion and motor deficits by its antioxidative and anti-inflammatory properties in Parkinsonian rats. Pharmacogn Mag 14(53):9-16
  71. Riaz Rajoka MS, Jin M, Haobin Z et al (2018) Impact of dietary compounds on cancer-related gut microbiota and microRNA. Appl Microbiol Biotechnol 102(10):4291-4303
  72. Sarker MR, Franks SF (2018) Efficacy of curcumin for age-associated cognitive decline: a narrative review of preclinical and clinical studies. Geroscience 40(2):73-95
  73. Schiborr C, Kocher A, Behnam D et al (2014) The oral bioavailability of curcumin from micronized powder and liquid micelles is signifi­cantly increased in healthy humans and differs between sexes. Mol Nutr Food Res 58:516-527
  74. Seo HJ, Wang SM, Han C et al (2015) Curcumin as a putative antide­ pressant. Expert Rev Neurother 15(3):269-280
  75. Shehzad A, Qureshi M, Anwar MN et al (2017) Multifunctional curcumin mediate multitherapeutic effects. J Food Sci 82:2006-2015
  76. Shen L, Liu L, Ji HF (2017) Regulative effects of curcumin spice administration on gut microbiota and its pharmacological implications. Food Nutr Res 61:1361780
  77. Shin HS, See HJ, Jung SY et al (2015) Turmeric (Curcuma longa) attenuates food allergy symptoms by regulating type I/type 2 helper T cells (Thl/Th2) balance in a mouse model of food allergy. J Ethnopharmacol 175:21-29
  78. Siard MH, McCurry KE, Adams AA (2016) Effects of polyphenols including curcuminoids, resveratrol, quercetin, pterostilbene, and hydroxypterostilbene on lymphocyte pro-inflammatory cytokine production of senior horses in vitro. Vet Immunol Immunopathol 173:50-59
  79. Small GW, Siddarth P, Li Z et al (2017) Memory and brain amyloid and tau effects of a bioavailable form of curcumin in non-demented adults: a double-blind, placebo-controlled 18-month trial. Am J Geriatr Psychiatr 26:266-277
  80. Sohrabi M, Alahgholi-Hajibehzad M, Mahmoodian ZM et al (2018) Effect of cinnamon and turmeric aqueous extracts on serum interleukin-l 7F level of high fructose-fed rats. Iran J Immunol 15:38-46
  81. Su L-Q, Di Wang Y, Chi H-Y (2017) Effect of curcumin on glucose and lipid metabolism, FFAs and TNF-a in serum of type 2 diabetes mellitus rat models. Saudi J Biol Sci 24:1776-1780
  82. Subhashini PS, Chauhan S, Kumari Set al (2013) Intranasal curcumin and its evaluation in murine model of asthma. Int Immunopharmacol 17(3):733-743
  83. Subhashini PS, Chauhan S, Dash D et al (2016) Intranasal curcumin ameliorates airway inflammation and obstruction by regulating MAPKinase activation (p38, Erk and JNK) and prostaglandin 02 release in murine model of asthma. Int Immunopharmacol 31:200-200 Sundaram JR, Poore CP,
  84. Sulaimee NHB et al (2017) Curcumin ameliorates neuroinflammation, neurodegeneration, and memory deficits in p25 transgenic mouse model that bears hallmarks of
  85. Alzheimer’s disease. J Alzheimers Dis 60:1429-1442
  86. Suresh D, Srinivasan K (2010) Tissue distribution and elimination of capsaicin, piperine and curcumin following oral intake in rats. Indian J Med Res 131:682-691
  87. Tanabe Y, Maeda S, Akazawa N (2015) Attenuation of indirect markers of eccentric exercise-induced muscle damage by curcumin. Eur J Appl Physiol 115(9):1949-1957
  88. Tian L, Zeng K, Shao W et al (2015) Short-term curcumin gavage sensitizes insulin signaling in dexamethasone-treated C57BL/6 mice. J Nutr 145:2300-2307
  89. Velusami CC, Richard EJ, Bethapudi B (2018) Polar extract ofCurcuma longa protects cartilage homeostasis: possible mechanism of action. Inflammopharmacology 26(5):1233-1243
  90. Verma S, Mundkinajeddu D, Agarwal A et al (2017) Effects of turmeric curcuminoids and metformin against central sensitivity to pain in mice. J Traditional and Comp! Med 7:145-151
  91. Vors C, Couillard C, Paradis ME et al (2018) Supplementation with resveratrol and curcumin does not affect the inflammatory response to a high-fat meal in older adults with abdominal obesity: a randomized, placebo-controlled crossover trial. J Nutr 148: 379-388
  92. Wojcikowski K, Vigar VJ, Oliver CJ (2018) New concepts of chronic pain and the potential role of complementary therapies. Altern Ther Health Med.
  93. Xu X, Cai Y, Yu Y (2018) Effects of a novel curcumin derivative on the functions of kidney in streptozotocin-induced type 2 diabetic rats. Inflammopharmacology.
  94. Yang JY, Zhong X, Kim SJ et al (2018) Comparative effects of curcumin and tetrahydrocurcumin on dextran sulfate sodium­ induced colitis and inflammatory signaling in mice. J Cancer Prev 23(1):18-24
  95. Yeon KY, Kim SA, Kim YH et al (2010) Curcumin produces an antihyperalgesic effect via antagonism of TRPVI. J Dent Res 89: 170-174
  96. Zhang DW, Fu M, Gao SH et al (2013) Curcumin and diabetes: a systematic review. Evid Based Complement Alternat Med:636053.
  97. Zhang Z, Leong DJ, Xu L et al (2016) Curcumin slows osteoarthritis progression and relieves osteoarthritis-associated pain symptoms in a post-traumatic osteoarthritis mouse model. Arthritis Res Ther 18:128-140
  98. Zhao M, Zhao M, Fu C et al (2018) Targeted therapy of intracranial glioma model mice with curcumin nanoliposomes. Int J Nanomedicine 13:1601-1610
  99. Zhi L, Dong L, Kong D et al (2013) Curcumin acts via transient receptor potential vanilloid-1 receptors to inhibit gut nociception and reverses visceral hyperalgesia. Neurogastroenterol Motil 25(6): e429-e440
  100. Zhu Q, Sun Y, Yun Z et al (2014) Antinociceptive effects of curcumin in a rat model of postoperative pain. Sci Rep 4:4932-4936

Important Notice

The indications provided on this page are suggested uses for each supplement based upon published clinical experience and/or scientific studies. They do not represent as cures or medical treatments and should be treated as advice only. The recommended doses may be provided in human form where dosing for animals has not been established. It is imperative that you understand that this information is provided as guidelines only. You should consult with a registered veterinarian before administering any nutraceutical. Where using a marketed product you should follow the manufacturers instructions.