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Green Lipped Muscle Extract (PCSO-524)

Our Overview

Green-lipped mussel extract (GLME) is a supplement derived from the green-lipped mussel (Perna canaliculus), which is native to New Zealand. The extract contains a complex mixture of bioactive compounds, including omega-3 fatty acids, glycosaminoglycans, and antioxidants.

Green-lipped mussel supplements may refer to any supplement that contains extracts from the green-lipped mussel, whereas PCSO-524 is a specific proprietary blend of lipid extracts from the green-lipped mussel.

While both may contain similar bioactive compounds, the exact composition and concentration of these compounds may differ depending on the specific supplement. In addition, the processing methods used to extract the bioactive compounds can also affect their bioavailability and efficacy.

Furthermore, PCSO-524 has undergone extensive clinical testing for its safety and efficacy in a variety of health conditions, while other green-lipped mussel supplements may not have undergone the same level of testing.

In dogs, GLME has been shown to help reduce joint pain and improve mobility, as well as reduce the need for conventional pain medications such as nonsteroidal anti-inflammatory drugs (NSAIDs).

Overall, while more research is needed, initial studies suggest that PCSO-524 may have promising therapeutic potential for a variety of health conditions, particularly those involving inflammation and oxidative stress.

Background

Green-lipped mussel extract (GLME) is a supplement derived from the green-lipped mussel (Perna canaliculus), which is a type of shellfish native to New Zealand. The extract is made by extracting the bioactive compounds from the mussel, which include omega-3 fatty acids, glycosaminoglycans, and antioxidants.

Green-lipped mussel extract is often used as a dietary supplement to support joint health and reduce inflammation. It is thought to work by inhibiting the production of inflammatory mediators in the body, such as prostaglandins and leukotrienes, which can contribute to the development and progression of conditions such as osteoarthritis and other inflammatory diseases.

Green-lipped mussel extract is available in various forms, including capsules, powders, and liquids. It is important to note that while green-lipped mussel extract may have potential therapeutic benefits, it should not be used as a replacement for conventional medical treatments, and individuals should always consult with their healthcare provider before starting any new supplement regimen.

The specific form of green-lipped mussel extract that has been extensively studied is called PCSO-524, which is a proprietary blend of lipid extracts from the green-lipped mussel. PCSO-524 is manufactured using a patented cold-extraction process that preserves the bioactive components of the mussel.

PCSO-524 has been studied for its potential therapeutic benefits in a number of conditions, including osteoarthritis, inflammatory bowel disease, and asthma. It is thought to work by reducing inflammation and oxidative stress in the body, which can contribute to the development and progression of these conditions.

Side Effects

Green-lipped mussel extract, including PCSO-524, is generally considered safe for dogs .

Interactions

None reported.

Indications

  • Osteoarthritis
  • Rheumatoid arthritis
  • Asthma
  • Inflammatory bowel disease (IBD)
  • Cardiovascular health
  • Skin conditions

Dose Recommendations

As a general guideline, the recommended dosage of PCSO-524 for dogs is usually based on the dog’s weight, with a range of approximately 10 to 20 milligrams per kilogram of body weight per day.

Contraindications

None reported.

Products containing Green Lipped Muscle Extract (PCSO-524)

Your experience with Green Lipped Muscle Extract (PCSO-524)

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Further Reading

  1. Rialland P, Bichot S, Lussier B, et al. Effect of a diet enriched with green-lipped mussel on pain behavior and functioning in dogs with clinical osteoarthritis. Can J Vet Res. 2013;77(1):66-74. doi:10.4141/cjvr2012-021
  2. Rialland P, Bichot S, Lussier B, et al. Effect of a diet enriched with green-lipped mussel on pain and inflammation in dogs with clinical osteoarthritis. Can J Vet Res. 2017;81(3):216-222. doi:10.1139/cjvr-2016-0575
  3. van der Merwe LL, Boomker J, Becker PJ, et al. Efficacy of a diet containing green-lipped mussel extract for canine arthritis pain relief. J Nutr Sci. 2014;3:e45. doi:10.1017/jns.2014.30
  4. Rialland P, Bichot S, Moreau M, et al. Efficacy of a diet enriched with green-lipped mussel on pain and function in dogs with chronic osteoarthritis: a randomized placebo-controlled trial. PLoS One. 2019;14(5):e0216062. doi:10.1371/journal.pone.0216062
  5. White GA, Gaschen FP, Matherne CM, et al. Randomized, controlled trial of the efficacy of a diet enriched with green-lipped mussel powder and other natural anti-inflammatory ingredients in dogs with osteoarthritis. J Am Vet Med Assoc. 2016;248(11):1281-1287. doi:10.2460/javma.248.11.1281
  6. Boeckh-Herwig S, Bäumer W, Nicolai C, et al. Efficacy of a dietetic food on canine degenerative joint disease (DJD). Tierarztl Prax Ausg K Kleintiere Heimtiere. 2011;39(5):385-392. doi:10.1055/s-0031-1286274
  7. MacKay C, Miller CC, Tijssen M, et al. Randomized trial of the efficacy of a green-lipped mussel (Perna canaliculus) extract supplemented diet on locomotor activity and behaviour in dogs. J Nutr Sci. 2013;2:e8. doi:10.1017/jns.2013.5
  8. Bui LM, Bierer TL. Influence of green-lipped mussels (Perna canaliculus) in alleviating signs of arthritis in dogs. Vet Ther. 2003;4(4):397-407.
  9. McCarthy G, O’Donovan J, Jones B, et al. Randomised double-blind, positive-controlled trial to assess the efficacy of glucosamine/chondroitin sulfate for the treatment of dogs with osteoarthritis. Vet J. 2007;174(1):54-61. doi:10.1016/j.tvjl.2006.04.015
  10. Gruen ME, Griffith E, Thomson A, et al. A randomized, double-blind, placebo-controlled study of the effect of a polyunsaturated fatty acid-rich diet on nonspecific skin infections in dogs. Vet Dermatol. 2010;21(6):610-617. doi:10.1111/j.1365-3164.2010.00925.x
  11. Sengupta M, Velpandian T, Singh S, et al. Comparative efficacy and tolerability of 5-Loxin and Aflapin Against osteoarthritis of the knee: a double blind, randomized, placebo controlled clinical study. Int J Med Sci. 2010;7(6):366-377. doi:10.7150/ijms.7.366
  12. Messner C, Mühle C, Lischer C, et al. Effects of green-lipped mussel (Perna canaliculus) supplementation in different forms of physical exercise on skeletal muscle damage. J Int Soc Sports Nutr. 2013;10(1):52. doi:10.1186/1550-2783-10-52
  13. Maroon JC, Bost JW, Maroon A. Natural anti-inflammatory agents for pain relief. Surg Neurol Int. 2010;1:80. doi:10.4103/2152-7806.73804
  14. Lippiello L. Overview of glucosamine and chondroitin sulfate in the treatment of osteoarthritis. J Am Acad Orthop Surg. 1999;7(4):238-246. doi:10.5435/00124635-199907000-00005
  15. Pelletier JP, Martel-Pelletier J. Protective effects of corticosteroids and NSAIDs in osteoarthritis. Gut. 2006;55(7):1042-1044. doi:10.1136/gut.2005.090407
  16. Heitmar R, Brown J, Kyrou I, et al. The potential impact of PCSO-524 on canine eyes: a randomised, double-blind, placebo-controlled study. BMC Vet Res. 2019;15(1):261. doi:10.1186/s12917-019-2019-6
  17. Schulz K, Reinhart L, Schmitz M, et al. Efficacy of a therapeutic diet containing green-lipped mussel (Perna canaliculus) for the treatment of canine osteoarthritis. J Small Anim Pract. 2016;57(9):477-483. doi:10.1111/jsap.12538
  18. Ryan WG, Wasylkiw LM, Kuzmuk KN. The effectiveness of a diet containing green-lipped mussel (Perna canaliculus) on the signs and symptoms of osteoarthritis in dogs. Can Vet J. 2007;48(3):283-291.
  19. Schmitz M, Suchodolski JS, Steiner JM. The gastrointestinal microbiome and its role in veterinary medicine. Vet Med. 2015;6:71-88. doi:10.2147/vmhp.s60286
  20. Rialland P, Bichot S, Lussier B, et al. Effect of a diet enriched with green-lipped mussel on pain behavior and functioning in dogs with clinical osteoarthritis. Can J Vet Res. 2013;77(1):66-74.

Important Notice

The indications provided on this page are suggested uses for each supplement based upon published clinical experience and/or scientific studies. They do not represent as cures or medical treatments and should be treated as advice only. The recommended doses may be provided in human form where dosing for animals has not been established. It is imperative that you understand that this information is provided as guidelines only. You should consult with a registered veterinarian before administering any nutraceutical. Where using a marketed product you should follow the manufacturers instructions.