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Dehydroepiandrosterone (DHEA)

Our Overview

DHEA (dehydroepiandrosterone) is an adrenal gland hormone that decreases dramatically with age. Purdue University researchers found that giving elderly dogs 100 mg/kg of DHEA daily as a supplement for seven months reduced the percentage of brain cells with extensive DNA damage by 42%. This suggests that even an elderly animal can benefit from anti-aging treatments. In the same study, damage to the dogs’ immune cells was cut in half. It is worth noting that both types of cells (immune and brain) are severely damaged in Alzheimer’s patients. DHEA’s ability to protect these vital cells may be attributed to its antioxidant activity.

Background

DHEA (and its sulfated metabolite, DHEA-S) are among the body’s most abundant naturally occurring steroids. DHEA is produced by the adrenal gland (near the kidney), the central nervous system, the gonads (testes and ovaries), the skin, and the gastrointestinal tract.

DHEA’s exact role is unknown at this time, but it does serve as a precursor for the synthesis of more than 50 different hormones, including androgenic and estrogenic steroids. In humans, the adrenal gland produces the most DHEA between the ages of 25 and 30. Levels fall with age and possibly during times of stress or serious illness.

DHEA supplementation may help prevent or reverse conditions associated with low endogenous DHEA levels, such as ageing, diabetes, cancer, and autoimmune diseases. DHEA may also help with hyper- and hypoadrenocorticism (Cushing’s and Addison’s disease, respectively), potentially improve mood and feelings of well-being in people with depression, and may reduce the risk of developing diabetes or improve diabetes treatment. DHEA precursors isolated from wild yams or soy are typically used to make supplements, which are then chemically synthesised into DHEA.

Side Effects

Long-term safety has not been established in any species through any well-designed clinical studies. DHEA is a precursor to a large number of hormones in the body, so unintended consequences are possible. People have reported abnormal liver function, slightly decreased haemoglobin and red blood cell counts, hirsutism, gynecomastia, aggressiveness, fatigue, headache, irritability, insomnia, and nasal congestion as side effects.

Interactions

DHEA should be avoided when taking benzodiazepines. This is due to the possibility of DHEA inhibiting benzodiazepine metabolism and benzodiazepines increasing endogenous DHEA levels. Patients taking anticoagulants must be closely monitored because DHEA can interfere with coagulation. Although anticonvulsant medications may lower serum DHEA levels, elevated DHEA levels caused by DHEA supplementation may inhibit anticonvulsant medication therapeutic action. Patients receiving DHEA and an anticonvulsant medication should exercise caution.

DHEA supplementation with clonidine and fluoxetine may have a therapeutic benefit. Oral corticosteroid therapy reduces serum DHEA and DHEA-S levels. DHEA supplementation for patients on long-term corticosteroid therapy may thus mitigate some of the negative side effects while maintaining the benefits of corticosteroid therapy. Combining DHEA and oestrogen may improve therapeutic efficacy and reduce side effects seen in women on estrogen/progesterone replacement therapy. However, combining DHEA and oestrogen has the potential to amplify the negative effects caused by elevated levels of either oestrogen or DHEA. Patients taking methyltestosterone and related medications have the same potential for reducing side effects, increasing efficacy, and possibly producing adverse effects.

Finally, DHEA may enhance the efficacy of thyroid medications, potentially increasing the risk of thyrotoxicosis.

Indications

  • Supports cancer patients
  • Helps patients with hyper- or hypoadrenocorticism

Dose Recommendations

In dogs and cats, a dose of 5 mg/9 kg of body weight per 24 hr period is suggested, with a stated range of 5–50 mg per 24 hr period. Some studies however trialled larger doses. As with people, dividing the dose and administering per 12 hr period may be preferred to maintain blood levels and more accurately reflect endogenous hormone secretion.

Contraindications

DHEA should not be used in patients with cancers caused by testosterone or oestrogen, though the 7-keto variant may be safe in these patients. DHEA supplementation may be especially beneficial in older patients; the elderly are more likely to have conditions such as benign prostatic hyperplasia and should be screened for these conditions before beginning DHEA supplementation. DHEA supplementation is not recommended for patients with insulin-dependent diabetes until more research is done. Close supervision and regular monitoring are recommended if used.

Products containing Dehydroepiandrosterone (DHEA)

Your experience with Dehydroepiandrosterone (DHEA)

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Further Reading

  1. Pizzorno J, Murray M, Joiner-Bey H. The clinician’s handbook of natural medicine. 2nd ed. St. Louis (MO): Churchill Livingstone; 2008:45.
  2. Stargrove M, Treasure J, McKee D. Herb, nutrient, and drug interactions: clinical implications and therapeutic strategies. St. Louis (MO): Mosby Elsevier; 2008:746–56.
  3. Fetrow CW, Avila J. Professional’s handbook of complementary & alternative medicines. 3rd ed. Philadelphia (PA): Lippincott Williams & Wilkins; 2004:280–5.
  4. Wynn S, Marsden S. Manual of natural veterinary medicine: science and tradition. St. Louis (MO): Mosby; 2003:200, 265, 272.
  5. Broadfoot PJ, Palmquist RE, Jonston K, et al. Integrating complementary medicine into veterinary practice. Goldstein R, ed. Blackwell; 2008:21–2, 513, 515. Available at: www.mediafire.com/?2s13ctmvv7tyb2k. Accessed January 15, 2012.
  6. Pizzorno J, Murray M. Textbook of natural medicine. 3rd ed. St. Louis (MO): Churchill Livingstone; 2006:899–904.

Important Notice

The indications provided on this page are suggested uses for each supplement based upon published clinical experience and/or scientific studies. They do not represent as cures or medical treatments and should be treated as advice only. The recommended doses may be provided in human form where dosing for animals has not been established. It is imperative that you understand that this information is provided as guidelines only. You should consult with a registered veterinarian before administering any nutraceutical. Where using a marketed product you should follow the manufacturers instructions.