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Dimethylglycine (DMG)

Our Overview

Dimethylglycine (DMG) is a supplement that is frequently used as a performance enhancer in racing animals like dogs and horses due to its alleged ability to reduce lactic acid buildup and thus muscle fatigue. It is a natural byproduct of choline metabolism and is a derivative of the amino acid glycine. Other reported uses/benefits in humans include autism, seizures, lupus, melanoma, diabetes, chronic fatigue syndrome, and improved immune and cardiovascular function, though many of these claims have not been supported by rigorous scientific research.

Limited studies in animals have been performed, but there is anecdotal evidence that dimethylglycine may benefit those with certain immune, cardiovascular, or metabolic diseases. However, better clinical trials must be performed to evaluate these possible benefits.

Background

DMG is produced in the body by the amino acid glycine. It is also made from choline and betaine. Betaine, in particular, contains three methyl groups (one carbon atom and three hydrogen atoms). DMG is the remaining product after one of the methyl groups is removed. The amino acid glycine and two formaldehyde atoms are then produced after DMG is oxidised. Folic acid is made from formaldehyde atoms (vitamin B9). DMG’s methyl groups are also used to synthesise choline, S-adenosylmethionine (SAMe), methionine, hormones, neurotransmitters, and DNA.

DMG, as an antioxidant, protects against radiation therapy and may help to reverse some of the negative effects of autoimmune diseases. DMG has an anti-inflammatory effect and may be useful in the treatment of inflammatory diseases such as osteoarthritis. DMG may assist patients in improving their (athletic) performance and endurance, improving circulatory and heart function, providing increased energy, and allowing patients to eliminate or significantly reduce their cardiac medications. DMG is a “anti-stress” compound that may be beneficial to any patient who is stressed. DMG has been shown in studies to improve the immune response by enhancing both cell-mediated and humoral immunity and stimulating the production of inflammatory mediators. DMG is present in low concentrations in foods such as meats, seeds, and grains.

Side Effects

DMG is considered extremely safe.

Interactions

None reported.

Indications

  • Supports the immune system
  • Helps patients with cancer
  • Fights infections

Dose Recommendations

In dogs and cats, Anecdotal doses of 450 mg/11.3 kg body weight per 12–24 hr period has been suggested. In the one clinician’s recorded experience, 125 mg/2.3–18.1 kg body weight per 12–24 hr period was articulated as potentially appropriate.

Contraindications

None reported.

Products containing Dimethylglycine (DMG)

Your experience with Dimethylglycine (DMG)

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Further Reading

  1. Pizzorno J, Murray M. Textbook of natural medicine. 3rd ed. St. Louis (MO): Churchill Livingstone; 2005:613, 1655.
  2. Schoen AM, Wynn SG. Complementary and alternative veterinary medicine: principles and practice. St. Louis (MO): Mosby; 1998:36–7.
  3. Kendall R. Building wellness with DMG. Topanga (CA): Freedom Press; 2003.
  4. Broadfoot PJ, Palmquist RE, Jonston K, et al. Integrating complementary medicine into veterinary practice. Goldstein R, ed. Blackwell; 2008:509,722–3. Available at: www.mediafire.com/?2s13ctmvv7tyb2k. Accessed January 15, 2012.

Important Notice

The indications provided on this page are suggested uses for each supplement based upon published clinical experience and/or scientific studies. They do not represent as cures or medical treatments and should be treated as advice only. The recommended doses may be provided in human form where dosing for animals has not been established. It is imperative that you understand that this information is provided as guidelines only. You should consult with a registered veterinarian before administering any nutraceutical. Where using a marketed product you should follow the manufacturers instructions.